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Index to Anti-Aging Medicine I-L || Home || ARC | ImmInst | SWL | Groups:LifeExtension |
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Anti-Aging Medicine | 1 | 2 | 3 | 4 || Labs | Foots | Refs | Sup Notes 1 | 2 | 3a | 3b | 4 | 5 | Vendors | Biblio | Change Log | Mortality Charts | Age Transformation Life Extension Magazine | IAAS | A4M | QC | Ray | Barron || Mechanisms of Aging | IN | SENS | MEME | METHUS || Springer | WSU A-B | C-D | E-H | I-L | M-O | P-R | S-U | V-Z || A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z |[ Wikipedia | Wikigenes | iHOP | SA Biosciences ]| Geron A, A', A'', B | TA Sciences | Sierra Sciences | Maximum Telomere Support | RevGenetics | Terraternal Search: Journals || Wα | Calc | Scirus | BioInfoBank | National Library of Medicine | NIH | Elsevier EMBASE | Ingenta Connect | MedLine | Science Direct Google |[ Google Patents | Patent Lens ][ Google Books | LibCong | Amazon | Powells ][ Google Scholar | Wikipedia ][ MedLib | LibWeb] | Merriam-Webster |
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Idebenone [IAAS/Idebenone, Books, Links, Papers, LifeExtension, Wikipedia] (QSA-10),(a synthetic analog of CoQ10, ubiquinone) [61], [39], [59]. [Smart Drugs/Idebenone, enhances serotonin levels and nerve growth factor levels, Google links, (4). Idebenone protects myelin sheaths in multiple sclerosis, developer Prof. Zs-Nagy, (4). See also Links/Idebenone enhances serotonin levels and Links/Idebenone boosts Nerve Growth Factor levels. IGF-1 [Wikipedia, Links/IGF-1 and aging, Books, LibCong/IGF-1, Papers, Patents, LifeExtension]. IGF-1 (TA/IGF-1) upregulates telomerase [Telomerase Activators/(9), Biocarta Pathways], and may be activated via HGH (TA/HGH) from, say, whey protein and exercise. Almost all human cells are affected by IGF-1. "IGF-1 strongly promotes the survival of vascular smooth muscle cells, wheras low plasma IGF-1 is associated with many cardiovascular risk factors... IGF-1 increases nitric oxide production via a PI3K-Akt cascade which increases vasodilation and ROS scavenging... Additionally, activation of IGF-1 receptor and Akt stimulates production of cardiomyocytes and stem cells." - The Biology of Human Longevity, Caleb E. Finch, p.8. "Genetic pathways that promote survival and enlongated life include the IGF-1 signaling pathway [Links, Images, Books, Amazon], dietary restriction, and the mitochondrial transport chain..." - from Introduction to Telomeres and Telomerase in Ageing, Disease, and Cancer; Molecular Mechanisms of Adult Stem Cell Aging, by Jerry W. Shay and K. Lenhard Rudolph, edited by K. Lenhard Rudolph, 2008. I believe that I am stimulating the IGF-1 pathway by doing exercises while full of whey protein (from bodybuilding powder, cottage cheese, or skim milk), which stimulates HGH, thereby activating the IGF-1 pathway. This is probably a key to the long lifetime of 94+ year-old bodybuilder Jack Lalanne (b. Sept 14, 1914). See IGF-1 for antiaging. "IGF-1(Insulin Growth Factor-1) is a compound produced primarily in the liver through a conversion of HGH (Human Growth Hormone). HGH is secreted by the pituitary gland and is essential for growth and optimum immune system function. " - See Now IGF-1 Lozenges for Anti-Aging [Links, NOW], and NOW IGF-1 Lipospray [A1, NOW] for sublingual administration (about $25.00 at Whole Foods), and IGF-1 telomerase activation [Links, Books]. See also the IGF-1 receptor [Wikipedia, Links]. IGF-1 is a risk factor in prostate cancer and breast cancer (Wikipedia). IGF-1 can induce hypertrophy of skeletal muscle and other target tissues. See Lawrence A. Wetterau, Malik J. Francis, Liqun Ma and Pinchas Cohen, Insulin-Like Growth Factor I Stimulates Telomerase Activity in Prostate Cancer Cells, The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 7 3354-3359, Copyright 2003. See IGF-1 from deer antler [Links]. Since IGF-1 increases the risk of prostate cancer by about 4x, a Prostate Specific Antigen (PSA) test is recommended in connection with the use of this class of product [LifeExtension/IGF-1 and Aging]. As Dr. Jerry Brainum recently pointed out in Iron Man, DHEA boosts IGF-1 levels [Links, Papers], as does bodybuilding exercise. Vitamin D is thought to make IGF-1 safe enough to use in connection with telomerase activation, preventing any cancers due to IGF-1. See Vitamin D inhibits IGF-1 associated cancer. Note that Medical Nutraceutics puts 2000 IU of vitamin D into their telomerase activator Maximum Telomere Support, which is based on Astragaloside IV. iGrowHair Telomerase [Site, Links, Links/telomerase excreting acidophilus, Wikipedia/acidophilus, Links/acidophilus, Links/telomerase excreting probiotics, Wikipedia/probiotics, Books/Probiotics]. For $1,999, you can experiment with the TeloGenesis product iGrowHair Telomerase, which is thought to stimulate hair growth via telomerase from live Acidophilus and probiotics. iHerb Life Extension Supplements [41]. Immortalism and Life Extension - Aleph/Trans/Immortalism and Life Extension links [44]. Immortality.org - Immortality, Inc. links [19]. Immortality Institute [Imminst.org, Links, Papers]. Immortal Cellular Phenotype [Amazon, LibCong/the immortal cellular phenotype, Links, Images, Books, Papers]. See also the youthful cellular phenotype [Amazon, LibCong/the youthful cellular phenotype, Links, Images, Books, Papers], the senescent cellular phenotype [Amazon, LibCong/the senescent cellular phenotype, Links, Images, Books, Papers], and the cancerous cellular phenotype [Amazon, LibCong/the cancerous cellular phenotype, Links, Images, Books, Papers]. See also lymphoma cells [Amazon, LibCong/lymphoma cells, Links, Images, Books, Papers], leukemia cells [Amazon, LibCong/leukemia cells, Links, Images, Books, Papers], and human cell types [Amazon, LibCong/human cell types, Links, Images, Books, Papers]. Immortomouse [Books, Links; Links/mouse genome, Images, Books] Immortomouse is a transgenic mouse [Books/transgenic technology, Links/transgenic mice, Images, Papers, Books, Amazon] carrying a temperature-sensitive SV40LT gene. A number of tissues from the mouse [Images] give rise to immortal cell lines, including cells from the colonic epithelium [Images], brain [Images], astroglia [Images], muscle [Images], and retinal epithelium [Images]. [Fenton & Hord, 2004; Nobel & Barnett, 1996; Ahmed et al, 2004; Su, et al, 2003]. Immunological Theory of Aging [Books, LibCong, Links, Papers, LifeExtension] (10). Indole-3-carbonol [GettingWell/Indole-3-carbonol, Links, Books, Papers, LifeExtension, Wikipedia], exhibits estrogen-modulating anti-cancer properties, [25f] Infectious Burdens and Aging [Links, Images, Books, LibCong/infections and aging, Papers, Patents, LifeExtension]. "High infectious burdens and poor nutrition attenuate somatic repair and growth." - The Biology of Human Longevity, C.E.Finch, p.4. Inflammation and Aging, [Books, Amazon, LibCong, Links, Papers, LifeExtension, Ben Best] see [70s], [68s] on NFκB, and [67s] on C-reactive protein as a marker of inflammation and aging. InfoAging, [57] Inflammatory factors secreted by senescent cells [Links, Images, Books, LibCong/senescent cells, Papers, Patents, LifeExtension] "have been implicated in focal remodeling of pre-malignant cells." - Caleb E. Finch, p.32. That is, inflammatory factors secreted by senescent cells may lead to cancer. Thus, telomerase activation with small molecule telomerase activators (7) to avoid replicative cellular senescence, reducing inflammatory factors and insuring genomic stability, protects against cancer. See IndexAB/anti-inflammatory nutraceuticals and IndexAB/Anticancer Diet. Infrared Spectroscopy [Wikipedia, LibCong, Links]. Inositol [Books, LibCong, Links, Wikipedia, LifeExtension]. Institute for Longevity Research [Links] [13]. Insulin Overload [LEF/Insulin Overload & appetite suppressant pinolenic acid, Links/Insulin Overload, Books, LifeExtension], Pinolenic acid. Insulin Resistance & Metabolic Syndrome - LEF/Insulin Resistance & Metabolic Syndrome, obese man's disease, [Links, Books, LibCong, LifeExtension]. Insulin Utilization Theory [Links/insulin metabolism, Books, LibCong/insulin utilization, LifeExtension], (6). Interferons [Wikipedia, Links, Books, LibCong/interferon, Amazon]. A subset of glycoproteins, cytokines, involved in the immune response to foreign RNA. Interleukins [Wikipedia, Books, LibCong/interleukins, Amazon]. Interleukin 2 [Intimm/Interleukin 2, Wikipedia, Books, Papers, Patents] for lymphocytes is a small-molecule telomerase activator. This is a larger molecule of about 15,500 Daltons (still capable of passing through the nuclear pore), the cytokine also termed IL-2 (interleukin 2), a "lymphokine" which augments the expression of mRNA for human telomerase in T-cell lymphocytes. IL-2 "has been approved by the Food and Drug Administration (FDA) for the treatment of cancers (malignant melanoma, renal cell cancer), and is in clinical trials for the treatment of chronic viral infections, and as a booster (adjuvant) for vaccines." - [Wikipedia]. Interleukin 2's telomerase-enhancing role in T-lyphocytes has been noted by other investigators. [Papers/IL-2 and telomerase activation; Papers/interleukin-2 and telomerase activation, Links, Books, article]. Interleukin 6 [Links, Books, Papers, Amazon] is an inflammatory cytokine produced by exercise that generates heat shock protein Hsp90, which is complexed with nuclear superfamily transcription factors prior to their transport into the nucleus. It may be important in the process of chain transporting cycloastragenol from the astragalosides into the nucleus. International Anti-Aging Systems IAAS, [57]. International Units (IU) [Links, Wikipedia, Links/International Unit conversion Table]. Intravenous Anti-Aging Therapies [Wikipedia, Books, Papers, Links, LifeExtension]. Intravenous techniques [Books, LibCong, Books/Intravenous Therapies]. Iron, Oxygen, and Free Radicals in Brain Aging [Books, LifeExtension, LibCong/Brain Aging], [11s]. Ischemia [Wikipedia, Links, Books, LibCong/Adult Stem Cells] - A restriction in blood supply, generally due to factors in the blood vessels, with resultant damage or dysfunction of tissue. Isoprostanes [Links, Books, Papers, LifeExtension], (1). Isothiocyanates, anti-cancer, from wasabi, broccoli, watercress, [Wikipedia, Books, LifeExtension]. Our Journals selection relevant to Anti-Aging Medicine. Journal of Anti-Aging Medicine on-line. See Journals. Journals of Gerontology series A, on-line. See Journals. Journal of Longevity and its archives on-line. See Journals. Juvetea, [Site] a telomerase activator. "Juvetea matches the best Green Oolong tea with ginseng and other herbs which contain a compound that activates the so called immortalizing enzyme telomerase in human cells." Keratosis [Links, Books, LibCong, Google Images/Keratosis, Wikipedia/actinic keratosis, Wikipedia/Seborrheic keratosis, Wikipedia/Keratosis pilaris, Books/actinic keratosis (images), Books/Seborrheic Keratosis (images), Books/Keratosis pilaris (images)]. Friendly Light Erbium Laser Skin Resurfacing. A keratosis, like a wart, is usually conveniently removed by cryosurgical technique, with liquid nitrogen or Compound W Freeze-Off. Kinetin [CosmeticsCop/Kinetin, Books, LibCong, Links, LifeExtension], possibly Hayflick limit extender, (7). Krill Oil [IAAS, Books, Links, LifeExtension] contains omega-3's like fish oil, and also phospholipids, especially choline, for membrane therapy. L-Dopa [Links/L-Dopa, LifeExtension, Books, LibCong, Links, Wikipedia] increases dopamine, then HGH levels. Laboratory Safety [Books, LibCong, Amazon]. Lamin A [Books, Wikipedia] [86], nuclear membrane protein involved in progeria and its premature aging. Laetrile [IAAS/Laetrile, James South on Laetrile, "vitamin B17 Books, Links, LifeExtension] (or amygdalin), this apricot kernel extract has been used for decades for cancer." Not FDA approved. (Lay a trill?). Labrusca grape [Wikipedia/Labrusca grape (Concord grape)], (0). LC-Mass (Liquid Chromatography with Mass Spectometry) [Links, Amazon, LibCong/Liquid Chromatography with Mass Spectroscopy, LibCong/Liquid Chromatography, LibCong/Mass Spectroscopy, Books]. LDL peroxidation [Links/LDL peroxidation, [Books, LibCong, Links, LifeExtension, Wikipedia], (1) Lee Priest (bodybuilding) [20]. Lesions, Skin [LibCong/skin lesions] __Solar Lentigo [images, Links, Books, Wikipedia], __Seborrheic Keratosis [images, Links, Books, Wikipedia], __Nevus [images, Links, Books, Wikipedia], __Achrocordon [Images, Links, Books], __Sebaceous Hyperplasia [Images, Links, Books], __Actinic Keratosis [Images, Links, Books], __Xanthelasma [Images, Links, Books], __Verruca Vulgaris [common wart, Images, Links, Books], __Milia [Images, Links, Books], __Syringoma [Images, Links, Books], __SCC in Situ [Images, images/Bowen's disease, Bowen's disease, Links, Books], __Melanoma [Images, Med.Utah/melanoma, Books, Links]. Many skin lesions, such as a keratosis or a wart, are conveniently removed by cryosurgical technique, with liquid nitrogen or Compound W Freeze-Off. Lewis bodies [Links/Lewis bodies in aging brain, Links/Lewy bodies in aging brain, Books/Lewy bodies in the aging brain, LifeExtension/Lewy bodies] & the Proteasome, [2s]. Life Expectancy Calculator - AgingResearch.org/Life Expectancy Calculator, [17]. Life Extension Manual [46]. Life Extension Mix Links/Life Extension Mix components, a closer look, [36s]. Life Extension, Life Extension Magazine online, [Books, LibCong, Links, Wikipedia] [38]. Life Extension Foundation, products from iHerb, [42]. Life Extension Magazine, [57]. Life span [Links, LifeExtension, Links, Wikipedia/Maximum Life Span] - mean and maximum life span, observations, mortality charts. Linus Pauling Institute, Linus Pauling and Vitamin C, [27]. Lipid Peroxidation [Links/Lipid Peroxidation, Wikipedia, Books, LibCong, Scholarly Papers, LifeExtension], inhibited by resveratrol and antioxidants, Zs.-Nagy on Lipid Peroxidation, Peroxidation of Fatty Acids, (0). Gamma tocopherol [Links, LifeExtension] is useful in preventing lipid peroxidation from peroxynitrites [Links, LifeExtension] generated by high Nitric Oxide levels that may physiologically useful in antiaging applications. Sesame seed oil is rich in gamma tocopherol and sesame lignans such as sesamin and sesamol that improve gamma tocopherol's antioxidant performance. Peanuts are another good source of gamma tocopherol. See also Reinald Pamplona and Gustavo Barja, Aging Rate, ROS Production, and Fatty Acid Unsaturation in Aging at the Molecular Level edited by Thomas von Zglinicki, 2003. Lipofuscin [Links/Lipofuscin, Wikipedia, Books, LibCong, Scholarly Papers] (See Ben Best on cellular garbage), Lipofuscin removal [LifeExtension, Books/Lipofuscin removal, Links/Lipofuscin removal, LifeExtension/Lipofuscin removal, Amazon/lipofuscin removal], in aging neurons, Zs.-Nagy on Lipofuscin, (4), (13) [4s]. Lipofuscin granules [Images] result from lysosomal digestion and are primarily a problem in post-mitotic cells including nerve cells, brain cells, muscle cells, and cardiac myocytes. Lipofuscin accumulation is a major risk factor in macular degeneration, Alzheimer's Disease, Batten's Disease, Parkinson's Disease, melanosis coli, denervation atrophy, and chronic obstructive pulmonary disease. - After Vince Giuliano in Anti-Aging Firewalls. See also ceroid-type lipofuscin from alcohol [Images/ceroid lipofuscin, Images/Neuronal ceroid lipofuscinosis]. Drugs effective in lipfuscin removal include CoQ10 (ubiquinol), piracetam, alpha lipoic acid, meclofenoxate (centrophenoxine), acetyl L-carnitine, and curcumin. Lipoic Acid [pronunciation, Wikipedia, Links, Books, LibCong, Papers, LifeExtension, Ben Best/Lipoic Acid] [70]. See alpha lipoic acid [Links], the most commonly available form. See also the more bioavailable forms of lipoic acid, R-lipoic acid and sodium-R-lipoic acid (Life Extension's Super R-lipoic acid). Lipoic acid supplementation reduces free iron levels, Lipoic acid links, see Alpha Lipoic Acid, In skin creams "lipoic acid helps remove glycated collagen." (LE), [see Ultra Rejuvenex.] (1). Lipoprotein phospholipase A2 (Lp-PLA2) [Books, LifeExtension, Wikipedia] High levels indicate that the patient has inflamed atherosclerotic plaques in which LDL oxidation is taking place. Omega-3 fatty acids and niacin may help in lowering levels. Curcumin may inhibit formation. See Life Extension's Endothelial Defense [Books], with cocoa, pomegranate, and GliSODin. Liposomes [pronunciation, Wikipedia, Links, Books, LibCong, Papers, LifeExtension] [68]. Liposome Creams [Links, Links/Lipsome cream kits]. See Encapsula Nano Sciences, FormuMax Scientific, NOF Corporation/Phospholipids for Liposomes, Microfluidics. Liposome Delivery Systems [Links, Books, LibCong, Links/Liposome Delivery Kits]. Liposome Technology [Links, LibCong, Papers, Patents, Books]. Livagen (Lys-Glu-Asp-Ala) [Paper, Links, St. Petersburg Institute of Biogregulation and Gerontology]. A peptide bioregulator. "Livagen induces activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin, and release of genes repressed due to age-related condensation of euchromatic regions in chromosomes. Results indicate that Livagen causes de-heterochromatinization (activation) of chromatin, which is realized via modification of heterochromatin and heterochromatinized regions in chromosomes from old people." Longevinex - Longevinex resveratrol links. Longevity, [Wikipedia, Wikipedia/senescence, LibCong/Longevity], [37]. Longevity, the Journal of - The Journal of Longevity, [57]. Longevity genes [Wikipedia, Links, Books, LibCong, Papers, LifeExtension, Ben Best], [83], (0). Longevity genes SIR2 and SIRT1, [Wikipedia, Links, Books, Papers, LifeExtension], Longevity gene search at Centagenetics, Longevity genes found on Chromosome 4. (CNN), Longevity Gene Search Project, Longevity genes numbering about 200 found by UCSF scientists., Longevity genes sought at Albert Einstein School of Medicine, (0). 5-LOXIN [Links, LifeExtension] A patented extract from the boswellia plant [Links, LifeExtension] shown to suppress the dangerous enzyme 5-lipoxygenase [Links] and other pro-inflammatory factors [Links] . Lucidril (Centrophenoxine) [Smart Drugs/Lucidril, See Centrophenoxine Books, LibCong/Centrophenoxine, Links, LifeExtension), Links/Lucidril, (4)]. Lutein [Lutein.Info, pronunciation, Wikipedia, Links, Books, LibCong, Papers, LifeExtension], zeaxanthin, and meso-zeaxanthin aid against macular degeneration, [25i], [101]. Lutein also protects against cataracts [Wikipedia, Links, Books, LifeExtension], which increase as sun exposure goes up. "Scientists found a 40% lower rate of cataracts occuring at the center of the lens for every milligram increase in their daily intake of lutein and zeaxanthin!" - LifeExtension. See Foods Containing Lutein and Zeaxanthin [Links, LifeExtension]. Green vegetables such as kale, spinach, turnip greens, collard greens, romaine lettuce, broccoli, zucchini, garden peas and Brussel sprouts are the finest sources of lutein and zeaxanthin. Luteolin [Wikipedia, Links, Books, Papers, LifeExtension], (combats proliferation of undesirable cell colonies), found in high amounts in parsley, sage, and peppermint along with basil, celery and artichoke, also found in celery, green pepper, perilla and camomile tea [36s] (g). Luteolin is also used to suppress dangerous inflammatory cytokines [Links, Books], such as interleukin-1 and tumor necrosis factor alpha. Lycopene [Links, LibCong, LifeExtension, Wikipedia; Links/Lycopene in foods] Lycopene, an antioxidant, is superior for decreasing blood lipid levels, application to oxidized LDL, and inflammation. It slows the accumulation of atherosclerotic plaque, and is associated with healthier prostate function. Take at least 10 mg/day. Note that lycopene is best absorbed from processed or heated tomato-based products rather than from raw tomatoes. Lymphoma [Links, Books, Wikipedia, DNA Microarray Lymphoma study, Amazon, LibCong] Lymphoma induced by dying his hair [see Hair Dye Mutagenic Carcinogens] killed Steve Reeves [web site] at 74 after his lymphoma metastasized. Reeves died at Palomar Medical Center in Escondido, Calif. just eight weeks after his diagnosis. He was cremated and his ashes were scattered in Montana. The 4 occipital lymph nodes at the base of the skull-neck junction on both the left and the right drain the scalp over the occipital region of the skull. [Links/occipital lymph nodes, Books/occipital lymph nodes, Links/Steve Reeves dies of lymphoma, Causes of Lymphoma]. Monoclonal antibodies for treating lymphoma include Rituxan - (generic name rituximab, British trade name MabThera) a nonradioactive bound monoclonal antibody recently approved by the US Food and Drug Administration (FDA), Zevalin - an investigative drug from the makers of Rituxan with yttrium-90 radiolabel, and Bexxar - the first radiolabled antibody is in phase III trials and is receiving wider distribution and publicity prior to approval. See Hodgkin's Disease, and Lymphomas (Non-Hodgkins). See also Symptoms: Swollen Lymph Nodes. I expect non-Hodgkins lymphoma from hair dye to show up in the occipital lymph nodes at the back of the neck, in the retroauricular lymph nodes behind the ear, or in the parotid lymph nodes in front of the ear. [Chart] See also [Books/removing the occipital lymph nodes, Books/occipital lymph node surgery, Books/occipital lymph node biopsy, Neck surgery procedure, occipital anatomy 1, 2, Links/occipital artery, Books/Local anesthetic, Links/Local anesthetic, Wikipedia/local anesthetic, Books/melanoma, Books/lymphatic melanoma, Books/lymphoma, Books/treating lymphoma, Links/treating lymphoma, Famous Victims of Lymphoma]. Sometimes swollen lymph nodes may be reduced by treatment with hot wet packs featuring a hot wet hand towel warmed by a hot water bottle, 4-6 times per day, 1/2 hour per treatment, to improve circulation to the node. Shark liver oil [Links, Wikipedia, LifeExtension] is a folk remedy for swelling of the lymph nodes. Lysosomes and Lipofuscin Removal [Links/Lysosomes, Links/lipofuscin removal, Links/Lysosomes and Lipofuscin Removal, Books, Papers, LifeExtension, Books/Lipofuscin removal, Links/Lipofuscin removal, LifeExtension/Lipofuscin removal, Amazon/lipofuscin removal], [4s]. Lycopene [Lycopene.org, Books, LibCong, Links, Wikipedia, Amazon], Lycopene links from Tomatoes, [25h]. |
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